|
KMID : 0900920000240010041
|
|
Korean journal of Animal Reproduction
2000 Volume.24 No. 1 p.41 ~ p.47
|
|
|
Function of Constitutively Activating Lutropin/Choriogonadotropin Receptor
|
|
Min K.-S.
|
|
|
Abstract
|
|
|
|
Gonadotropin receptors are members of the seven-transmembrane (TM) receptor family, Point mutations in the lutropin/choriogonadotropin receptor (LH/CGR) have been shown to cause constitutive activation which results in precocious puberty in affected males, We introduced one of the mutation, D556Y, into the LH/CG receptor and the same high affinity binding mutant (D556Y) receptor clone cell for wild type LH/CGR (LH/CGR-wt) was chosen for further analysis, In contrast to cells expressing LH/CGR-wt, it was demonstrated that the mutant receptor exhibited markedly increased basal cAMP production in the absence of agonist, suggesting that autonomous Leydig cell activity in familial male-precocious puberty (FMPP) is caused by a constitutively activating LH/CGR.
|
|
|
KEYWORD
|
|
|
LH/CG receptor, Constitutively Activating LH/CG receptor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|